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CRF2 Cleanroom Foggers


Cleanroom Fogger Performance Comparisons

CRF4 Cleanroom Fogger VIDEO

CRF2 Cleanroom Fogger VIDEO

AP35 Ultrapure Fogger VIDEO


The CRF2 Cleanroom Fogger is a low cost, ultrasonic fogger using 9 high performance, piezo devices to create 0.26 cubic meters per minute (9 cubic feet per minute) of pure fog with a fog density of 57 ml fog density per minute for a typical 50 minute operation. This provides about 6-7 feet of visual fog for for smoke studies and air flow characterization in small areas such as fume hoods, airflow hoods, glove boxes and small bio-safety cabinets. The CRF2 is compatible with USP 797 Pharmaceutical In-situ Airflow Analysis; USP 800 Compound Pharmacy airflow tests; Airflow Recovery Tests in ISO 14644-3 Annex B12; Airflow Visualization Tests for ISO 14644-3 Annex B7; NSF 49 for Bio-Safety Cabinets; and Semi-Standards Clean Room Guidelines, Federal Standard 209E.


CRF2 Cleanroom Fogger produces ≈ 0.26 cubic meters of fog / minute, ≈ 57 ml fog density / minute, ≈ 50 minutes operation, ≈ 6-7 feet visual fog distance, 1 fog output.

The CRF2 Cleanroom Fogger is typically used in fume hoods and airflow hoods to generate 0.26 cubic meters pure fog per minute to visualize airflow patterns and turbulence in smoke tests of ISO suites and semiconductor clean rooms. USP 797 In-situ Airflow Analysis and ISO 14644-3, B7 guidelines support smoke studies. Airflow Recovery tests using PSL spheres and the CRF2 Cleanroom Fogger are guided by ISO 14644-3, B-12. The CRF2 would typically be used in smaller airflow areas, such as fume hoods, airflow hoods, small glove boxes using ISO 14644-3 Annex B7 or USP 797 in smoke studies.

Cleanroom Fogger, CRF2 Features – Click here for Cleanroom Fogger Video

  • 9 transducers converting DI Water or WFI water directly to 0.26 cubic meters of of pure fog for 50 minutes
  • Quick refill of Di Water or WFI water for continuous fog use
  • Easy to Fill 3.75 liters of DI water or WFI water
  • Visual Water Level Indicator provided
  • Hold Handle provides easy carry of tool
  • Polypropylene white enclosure is particulate free, no finger prints, less weight
  • Fog Curtain Wand, optional, plugs into end of Fog Hose to create a wide fog wall, while reducing the fog velocity and maintain a constant fog output
  • 2.5″ fog hose Diameter, which telescopes from 28 inches to 82 inches length
  • Fog Tube, power supply (120VAC or 220VAC) and 10 foot power cable provided
  • Easy to use, quick operation set up, instant On/Off fogging operation
  • Rolling Carry Case, optional, for carry and storage of Cleanroom Fogger
  • Remote Power Cable with ON/OFF switch to operate fogger behind closed walls or in a barrier isolator
  • Paperless operation – instructions and applications on the right side of the CRF2

In 2001 cleanroom foggers were developed, and since then, Applied Physics has supported smoke studies and smoke tests using a variety of cleanroom foggers. You can review cleanroom fogger performance for your smoke study. Our CRF2 portable fogger is low cost using ultrasonic piezo devices to visualize airflow and turbulence in fume hoods, airflow hoods, glove boxes, etc. The CRF2 is by far our best selling, low cost smoke machine due to its small size and constant fog volume. Fog volume is a primary requirement for a customer when purchasing a smoke machine. Fog density is usually unknown and not understood, but is the second most important reason for buying a fogger; as density controls the distance the airflow patterns and turbulence will be visible. To calculate fog density, find out the actual fill volume of the fogger and the actual operational time of fog. Ultrasonic foggers use an transducer assembly under water, which when powered generates fog vapor used to visualize airflow turbulence. Fog is also used to locate areas where there is minimal cleanroom air, called dead spots. Which ultrasonic fogger is the best for the money invested? Are you looking for a low cost cleanroom fogger with a constant fog volume? Or do you need a smoke machine that provides adjustable fog volume, adjustable airflow velocity and offers wireless remote control? The CRF2 fogger uses 3.75 liters and a single high output transducer assembly using 9 piezo devices. Fog density is 57ml per minute, which creates about 9 cubic feet per minute of fog during a typical 50 minutes of operation. The Cleanroom Fogger is a low cost device and typically used in fume hoods, airflow ducts and similar small areas. The Cleanroom Fogger uses DI water or WFI water to produce a pure fog to visually describe airflow movement, imbalance and areas with poor air movement in semiconductor clean rooms, pharmaceutical ISO suites, bio-safety cabinets, compound pharmacies and medical rooms. This low cost, CRF2 fogger is used in Pharmaceutical fume hoods, flow hoods, glove boxes and similar small areas. The Cleanroom Fogger uses DI water or WFI water to produce a pure fog to visually describe airflow movement, imbalance and areas with poor air movement in semiconductor cleanrooms, pharmaceutical ISO suites, bio-safety cabinets, compound pharmacies and medical rooms. This low cost, CRF2 fogger is used in Pharmaceutical fume hoods, flow hoods, glove boxes and similar small areas.The CRF2 is used in smoke studies and often referred to as a smoke generator or smoke machine used to model airflow movement and visualize airflow patterns and turbulence in fume hoods, airflow hoods, glove boxes etc. used in ISO 3, ISO 5, ISO 7 and ISO 9 suites. The CRF2 provides instant on and instant off operation. Smoke studies are typically completed using USP or ISO guidelines.

Clean Room Fogger

Cleanroom Fogger, ISO Suites, Sterile Rooms

  • Supports 100:1 Airflow Recovery Test, as defined in ISO 14644-3, B12
  • Supports airflow visualization tests supporting ISO 14644-3, B7
  • Supports airflow visualization analysis, USP 797 Guidelines
  • Supports airflow tests, NSF 49 National Safety Foundation
  • Supports airflow visualization, USP 800 Hazardous Drug Compounding
  • Supports Semiconductor Semi-Standards Guidelines
  • Air flow and pressure balance between two clean areas
  • Leak detection of exhaust ducts
  • Barrier Isolator and laminar flow tests
  • Wet bench exhaust tests
  • Personal safety exhaust tests
  • Chemical process equipment, exhaust ventilation tests

Compare Cleanroom Fogger

Product ModelCRF4 Portable Cleanroom FoggerCRF2 Cleanroom FoggerSmall LN2 Foggers
FOG Minutes~ 45 minutes~ 50 minutes~ 20-40 minutes
FOG Volume Meters/Min.~ 1.25 cubic meters / minute~ 0.26 cubic meters / minute~ 0.8 to 1.5 cubic meters / minute
Total FOG Volume~ 56.25 cubic meters~ 13 cubic meters~ 16 to 60 cubic meters
Fog Density (ml/minute)~ 187 mL / minute~ 57 mL / minute~ 150ml to 260 mL / minute
Visual Fog Distance~ 10 to 15 feet using Dual Fog Hose output~ 6 to 7 feet~ 10 feet
Adjustable Fog VolumeYes, thru touch pad and wireless remote controlNo fog volume controlNo fog volume control
Adjustable Airflow VelocityYes, thru touch pad and wireless remote controlNo airflow controlNo airflow control
Fogger TechnologyUltrasonicUltrasonicUltrapure
Liquids UsedDI Water, WFI or Sterile waterDI Water, WFI or Sterile waterLN2 + DI Water
Typical Use
Fume hood, airflow hood, small glove boxClean room, sterile room ISO suiteClean room, sterile room ISO suite
Compatible GuidelinesUSP 797USP 797USP 797
Compatible Guidelines ISO 14644-3, Annex B7ISO 14644-3, Annex B7ISO 14644-3, Annex B7
Compatible Guidelines Federal Standards 209EFederal Standards 209EFederal Standards 209E
Compatible Guidelines ISO Standard 14644-1, 14644-2ISO Standard 14644-1, 14644-2ISO Standard 14644-1, 14644-2
DI / WFI Water Volume9.0 liters3.75 liters2 liters
LN2 VolumeNo LN2 usedNo LN2 used9 liters
Operator ControlTouch pad control of fog volume & airflowPower Switch, no fog controlsPower Switch, no fog controls
Remote ControlWireless Remote control of fog volume & airflowRemote Cable Control, 10 feetNo Wireless Remote Control of fog
HandlingCarry Handles (top and front)Carry Handle (top)Carry Handle
Enclosure316L Stainless Steel, electro-polishPolyethyleneStainless Steel
Power VAC120, 220, 100 VAC120, 220, 100 VAC120, 220, 100 VAC
Full Weight~ 65 lbs~ 20 lbs~ 50-75 lbs
Accessories1-12 Accessories1-3 Accessories
Several Accessories


The CRF2 smoke machine is used in smoke studies as a smoke generator. It is a low cost device providing excellent volumes of fog in smoke studies. It provides a lower weight using a polypropylene enclosure, as compared to stainless steel enclosures. Operation instructions are located on the right panel, so there is no paper paper manuals used in the pharmaceutical ISO 9 suites, laboratory or clean room.

Theory of Operation: Ultrasonic cavitation and DI water or Pharmaceutical WFI Water. Use of any other liquids or chemicals voids the warranty.

The transducer life is ~5,000 hours. To protect the transducers from damage there is a level sensor that will interrupt the input voltage to the transducer module, should the water level drop to a low level. This ensures long life and reliability.

  1. The fog generated by this device contains microscopic droplets of DI water. AVOID USING IN IMMEDIATE VICINITY OF ELECTRICAL APPLIANCES, WATER SENSITIVE PRODUCTS AND EQUIPMENT.
  2. The fan will operate with no water in the reservoir with the power switch in the ON position. This will aid in drying when the chamber is drained.
  3. To increase drain plug tension, remove the plug, rotate clockwise (CW) the front latch while holding the rear metal disk.
  4. The CRF2 is intended to be used on a flat surface, on its feet. Tipping the fogger with water in the reservoir will damage the fogger. DO NOT OVERFILL OR TIP THE FOGGER.

Which Cleanroom Fogger or Smoke Generator Is Best For Smoke Studies?

AP35 Ultrapure Fogger, 5 Cubic Meters per minute for 70 minutes with 20-30 feet visible distance.
  • When ultrapure fog purity with high volume of fog and long visible airflow is needed
  • To visualizing airflow in large clean rooms, ceiling to floor
  • To fog exit velocity must not create turbulence
  • To needing to do 3D airflow modeling of airflow
  • When needing to do visualize airflow in larger clean rooms
  • When 70 minutes of high purity fog duration is needed
  • When fog visibility of 20-30 feet distance is required
  • To fog Class 1 to Class 10,000 semiconductor, medical, pharmaceutical cleanrooms
AP100 LN2 UltraPure Fogger, 15.5 Cubic Meters fog per minute for 70 minutes with 30-40 feet visible distance.
  • When ultrapure fog is needed to support large cleanrooms
  • Four Fog hoses and two water heaters are provided to disperse 15.5 cubic meters fog per minute
  • High levels of fog density to visualize airflow for 30-40 feet
  • For 3D airflow modeling of ISO suites, sterile rooms, cleanrooms
  • 9 Accessories available to configure the AP100 to your clean rooms
  • Fog large hallways and large clean areas
  • Fog for longer distances of 30-40 feet
  • Supports ISO 14644-3 and USP 797 airflow guidelines for your smoke study

* Use Hand Gloves and Face Shield when filling LN2
Use 16 Megohm DI water or WFI Pharmaceutical Water

CRF2 Cleanroom Fogger, 9cfm, 50 minutes Operation
  • When budget is lower, basic Fogger OK, minimal output turbulence
  • When 50 minutes of fog duration is useful with quick turnaround
  • When fog visibility for 6-7 feet distance is acceptable
  • When fogging gray areas behind the clean room
  • When fogging ≥ Class 10 or above in semiconductor or pharmaceutical clean rooms
CO2 Fogger, Vapor DiH2O Fogger, average 4cfm over 10 minutes
  • When Fogging Hazardous areas, No Electrical Outlet Available
  • When fog visibility for 5-6 feet distance is acceptable
  • When 10 minutes of fog duration is useful
  • When fogging small areas
  • Class 10 or above in semiconductor or pharmaceutical clean rooms
  • When fogging work benches

16 Meg ohm De-Ionized water, WFI water or Sterile water
Do not permit DI Water to go stagnant in the water chamber
** Use gloves when handling CO2 ice

Fogger Technology

The three types of foggers manufactured for use in cleanrooms, ISO suites and sterile rooms are described below.

Ultrapure LN2 Fogger: LN2 foggers use liquid nitrogen and DI Water or WFI water, providing the highest fog volume, highest fog density and best level of fog purity fog. Fog purity is allowing the LN2 to boil, while heating the water. nitrogen and water molecules form and combine at high rates to create a fog vapor. This process removes any bacterial agents and residual particulate matter from the water vapor. The volume of fog produced depends on the version of LN2 fogger purchased. The AP35 Ultrapure Fogger converts 571 ml of water per minute, a high fog density, which generates 5 cubic meters of fog for about 70 minutes to visualize airflow for 20-30 feet. The AP100 LN2 Fogger converts 1520 ml of water per minute, a very high fog density, to produce 15.5 cubic meters of ultrapure fog for about 70 minutes visualizing air flow for about 30-40 feet using 4 fog outputs. The fog is ultrapure leaving minimal, if any, trace particles behind. It evaporates to its gaseous hydrogen, oxygen and nitrogen components, which are natural to the cleanroom environment. LN2 foggers are used in a Class 1 – 10,000 cleanrooms.

DI Water Fogger: This type of fogger has less fog density (less capability to visualize airflow) than the LN2 ultrapure foggers described above. But a DI Water Fogger has more fog density than the CO2 fogger described below. The DI water fog is generated by cavitation in water, producing a water vapor of 8-10 microns in diameter. If the facility manager operates a class 10 to Class 10000 Clean room, the use of a DI Water Fogger poses no problem. However, Cleanroom Engineers who manage facilities operating at Class 1 to Class 10 performance may desire to use an ultrapure fogger. Although some DI Water foggers are described as ultrapure, but unless the DI water is heated or boiled to remove bacterial agents, the fog is not ultrapure. The 2-3 lb output pressure of a DI water fogger may also distort the airflow patterns. The temperature output is typically less than the surrounding room temperature, thus a fog generated from an ultrasonic fogger will sink momentarily in a typical 70 degree room temperature.

CO2 Fogger: This type of CO2 Smoke Generator produces an excellent volume of fog during the first minute, then begins to lose fog volume and fog den sity as the CO2 ice evaporates. CO2 fogger is used for low volume, non-process critical applications such as bench airflow testing. The fog is created using CO2 ice as the fogging agent. The fog contains elements of the CO2 and the user must determine if the residual CO2 components are acceptable in a process environment operating Class 100 to Class 10,000. The 2-3 lb output pressure of a CO2 fogger also distorts the airflow patterns, thus adding to the turbulence. The output starts at about 3cfm and slowly decreases to 0 CFM in about 10 – 12 minutes.

CRF2 Cleanroom Fogger From Applied Physics Inc.CRF2 Cleanroom Fogger From Applied Physics Inc.


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