How Polarizing Biological Microscopes Enhance Cellular Contrast

Conventional brightfield microscopes struggle to capture highly detailed images of transparent living cells without applying chemical stains. While staining provides contrast, it often alters or destroys the living state of the biological sample. Polarizing biological microscopy solves this issue by exploiting a physical property inherent to many native molecular structures: optical anisotropy or birefringence (Koike‐Tani […]
