Applied Physics · Precision technologies since 1992
Biological samples are stored at −150∘C for long-term preservation, where metabolic and enzymatic activity becomes extremely low.
Mechanical cryogenic freezers reduce the need for LN2 supply and handling, while also lowering safety risks.
The 138L model is suitable for smaller laboratories, while the 226L model is better suited to laboratories and biobanks with larger sample storage needs.
Before comparing capacities, it helps to understand why facilities choose mechanical cryogenic freezers over standard LN2 tanks.
Selecting between a 138L and a 226L cryogenic freezer depends on three primary factors: current and projected sample density, physical floor space, and power infrastructure.
The most obvious difference between the two units is usable interior volume.
Both sizes utilize a chest freezer configuration to minimize cold air loss during lid openings. Because cold air is denser than warm air, chest units retain their temperature far better than upright units when opened.
However, chest freezers occupy significant floor space. Measuring door clearances, hallway turns, and designated floor areas is essential before installation.
A –150°C freezer requires robust cascade refrigeration compressors to reach and hold deep cryogenic temperatures. A larger chamber (226L) requires slightly higher power draw and generates more heat output into the room than a 138L unit.
Your HVAC system must be capable of dissipating this heat load to maintain optimal ambient operating conditions (typically 15°C to 25°C).
The 138L model is a compact cryogenic storage solution designed for specialized workflows that prioritize precise sample grouping or limited footprint over raw storage volume.
The 226L model provides maximum volumetric efficiency for facilities managing large-scale archival projects.
By offering roughly 60% more internal storage space on a moderately larger footprint, it significantly lowers the cost per sample stored.
The following table highlights the core physical and functional specifications of both models.
| Specification | 138 Liters Model | 226 Liters Model |
|---|---|---|
| Internal Volume | 138 Liters (~4.87 cu. ft.) | 226 Liters (~7.98 cu. ft.) |
| Temperature Range | -40°C to -150°C | -40°C to -150°C |
| Cabinet Style | Heavy-duty Chest Type | Heavy-duty Chest Type |
| Interior Material | 304 Grade Stainless Steel | 304 Grade Stainless Steel |
| Approx. 2 mL Vial Capacity | ~9,000 to 10,000 vials | ~15,000 to 16,000 vials |
| Insulation Type | Vacuum Insulation Panels + Polyurethane | Vacuum Insulation Panels + Polyurethane |
| Control System | Microprocessor with Digital Touchscreen | Microprocessor with Digital Touchscreen |
| Primary Application | Specialized research, clinical trials, medium biobanking | Central repositories, core labs, large-scale biobanks |
| LN₂ Backup System | Compatible (Optional) | Compatible (Optional) |
Choosing between a 138L and a 226L -150°C cryogenic freezer comes down to your current sample inventory, expected growth, and available floor space.
If your facility requires a lower footprint, manages distinct smaller project batches, or operates with limited room, the 138L model provides exceptional performance and stability.
Conversely, if your goal is to maximize storage density, reduce cost-per-vial, and accommodate future biological archive expansion, the 226L model offers the best long-term value.
Assessing your lab’s infrastructure, door dimensions, and storage rack configurations today will ensure a smooth deployment and reliable operation for years to come.
A -86°C freezer is designed for short- to medium-term sample storage. A -150°C cryogenic freezer drops below the biological activity threshold (-135°C), making it suitable for indefinite, multi-year preservation without sample degradation.
Yes. These units use mechanical cascade refrigeration systems powered entirely by electricity. Liquid nitrogen is only required if you choose to install an optional emergency backup system for power outages.
Depending on the rack setup and box configurations, the 138L model holds approximately 9,000 to 10,000 standard 2mL vials, while the 226L model accommodates up to 15,000 to 16,000 vials.
The room must have adequate ventilation or air conditioning to handle ambient heat output, a stable ambient temperature between 15°C and 25°C, dedicated electrical circuits, and sufficient clearance around the freezer walls (at least 12 inches) for airflow.
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