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Cleanroom Fogger Comparison

Cleanroom Foggers Comparison

Smoke Studies and Airflow Visualization Study

Type of Fog Produced

Visual Fog Volume

Approximate Milli-liters of Liquid converted to Fog / Minute

Typical Visible Fog Time (dependent on fog velocity, fog volume and room humidity)

Typical Fog Distance

What Liquids are Used

Typical Shipping Dimensions of main Box

Accessories

Power Connections

CRF2-H Portable Cleanroom Fogger

Low-cost, 9 ultrasonic piezos, single 60mm fog outlet, pure fog output, polyethylene enclosure. Used in fume hood, small glove box, small airflow hood.

about 0.28 cubic meters / minute

About 50 ml liquid converted to fog each minute (fog density) using 9 ultrasonic piezo devices.
One 60mm fog outlet.
WATCH CRF2 VIDEO

typical, 45 minutes

Typical 6-7 feet visual fog airflow

De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

CRF2-H ships in box, or optionally in a 33x28x17" Rolling Carry Case. 4 optional accessories.

1) 22" Fog Curtain Wand
2) 10 ft Remote Control Cable
3) Rolling Carry Case w/ Foam Insert
4) Drain & Dry Kit.

Separate Power Supply & Cable, 115 VAC, 60 Hz; 220 VAC, 50 Hz.

CRF2-J Portable Cleanroom Fogger with 2Mx80mm Fog Hose

Low-cost, 12 ultrasonic piezos, single 80mm fog outlet, pure fog output, polyethylene enclosure. Used in medium glove box, RAB, small BSC, small airflow hood.

about 0.43 cubic meters / minute

About 64 ml liquid converted to fog each minute (fog density) using 12 ultrasonic piezo devices.
One 80mm fog outlet and Wireless Remote On/Off Key Fob.
WATCH CRF2 VIDEO

typical, 35 minutes

Typical 8-10 feet visual fog airflow

De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

CRF2-J ships in box, or optionally in a 33x28x17" Rolling Carry Case. 12 optional accessories.

1) 80mm x 0.6 M Fog Wand
2) Wireless Remote Control
3) 2M x 80mm Fog Hose
4) Dual 2M x 50mm Hose + 0.6M Fog Wand
5) Y Adaptor w/ Butterfly Valves
6) Plain Y Adaptor
7) 80mm T Adaptor
8) LED Fog Contrast Light
9) Accessory Rolling Carry Case w/ Foam Insert
10) 80mm x 2.4M Fog Wand for BSC, Isolator, cleanroom
11) 250mm Fog Nozzle
12) Drain & Dry Kit.

Integrated Power Supply & Power Cable, 115 VAC, 60 Hz; 100 VAC, 50 Hz; 220 VAC, 50 Hz.

CRF3 Portable Cleanroom Fogger

Adjustable control, pure fog output, single 80mm fog outlet, 316L electro-polished brushed stainless steel enclosure with Carry Handles. Used in small BSC, Barrier isolator, RABs, medium glove box smoke studies.

about 0.89 cubic meters / minute

about 133.57 ml liquid converted to fog each minute (fog density) using 25 ultrasonic piezo devices.
One 80mm fog outlet with 80mm hoses and 50mm hose adaptors.
Adjustable fog volume and airflow velocity, optional wireless remote control.
Legacy CRF4 demonstration — portable cleanroom fogger
Legacy CRF4 demonstration — bio-safety cabinet smoke study

typical, 70 minutes at max fog volume

Typical about 10 feet visual fog airflow

De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

CRF3 ships in box, 32 x 18.5 x 19 inches. Accessories in a separate Rolling Carry Cases.

1) 80mm x 1.2 M Fog Wand
2) Wireless Remote Control
3) 5M x 80mm Fog Hose
4) Dual 5M x 50mm Hose + 0.6M Fog Wand
5) Y Adaptor w/ Butterfly Valves or plain Y Adaptor
6) 80mm T Adaptor
7) LED Fog Contrast Light
8) Accessory Rolling Carry Case w/ Foam Insert
9) 80mm x 2.4M Fog Wand for BSC, Isolator, cleanroom
10) 250mm Fog Nozzle
11) Drain & Dry Kit.

Integrated Power Supply & Power Cable, 115 VAC, 60 Hz; 100 VAC, 50 Hz; 220 VAC, 50 Hz.

CRF6 Portable Cleanroom Fogger

Adjustable control, pure fog output and DUAL 80mm fog outlets, 316L electro-polished brushed stainless steel enclosure with Carry Handles. Used in medium USC, RAB, Barrier Isolator, small cleanroom or sterile smoke studies.

about 2.4 cubic meters / minute

about 256.3 ml liquid converted to fog each minute (fog density) using 48 ultrasonic piezo devices.
Two 80mm fog outputs with 80mm hoses and 50mm hose adaptors.
Adjustable fog volume and airflow velocity, optional wireless remote control.
Legacy CRF4 demonstration — portable cleanroom fogger
Legacy CRF4 demonstration — bio-safety cabinet smoke study

typical, 35 minutes at max fog volume or 50 minutes at lowest fog volume

Typical 12-15 feet visual fog airflow

De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

CRF6 ships in box, 32 x 18.5 x 19 inches. Accessories in a separate Rolling Carry Cases.

1) 80mm x 1.2 M Fog Wand
2) Wireless Remote Control
3) 5M x 80mm Fog Hose
4) Dual 5M x 50mm Hose + 0.6M Fog Wands
5) Y Adaptor w/ Butterfly Valves; or plain Y Adaptor
6) 80mm T Adaptor
7) LED Fog Contrast Light
8) Accessory Rolling Carry Case w/ Foam Insert
9) 80mm x 2.4M Fog Wand for BSC, Isolator, cleanroom
10) 500mm Fog Nozzle
11) Drain & Dry Kit.

Integrated Power Supply & Power Cable, 115 VAC, 60 Hz; 100 VAC, 50 Hz; 220 VAC, 50 Hz.

AP35 Portable Cleanroom Ultrapure Fogger

Provides a high volume of ultrapure fog using LN2 + (DI, Sterile or WFI) water, packaged in a 316L electro-polished, brushed, stainless steel enclosure on rolling SS frame (trolley). Used in smoke studies of large clean rooms and for visual fog in stage acting.

about 5.5 cubic meters / minute

about 571 ml liquid converted to fog each minute (fog density).
Adjustable fog volume, flow control, optional wireless remote control.
2 internal water heaters and ONE 80mm fog outlet.
Includes LN2 FLOW CONTROL to prevent LN2 valve freezing.
WATCH AP35 VIDEO

Typical 70 minutes

Typical 20-30 feet visual fog airflow

LN2 + De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

AP35 ships in crate: 1.2 M x 1M x 0.8 M. Accessories are in separate rolling carry cases.

1) 80mm x 1.2 M Fog Wand
2) Wireless Remote Control
3) 5M x 80mm Fog Hose
4) Dual 5M x 50mm Hose + 0.6M Fog Wands
5) Y Adaptor w/ Butterfly Valves; or plain Y Adaptor
6) 80mm T Adaptor
7) LED Fog Contrast Light
8) Accessory Rolling Carry Case w/ Foam Insert
9) 80mm x 2.4M Fog Wand for BSC, Isolator, cleanroom
10) 500mm Fog Nozzle
11) Drain & Dry Kit.

Integrated Power Supply & Power Cable, 115 VAC, 60 Hz; 100 VAC, 50 Hz; 220 VAC, 50 Hz.

AP100 Portable LN2 Fogger

Provides highest volume of ultrapure fog using LN2 + (DI, Sterile or WFI) water, packaged in a 316L electro-polished, brushed, stainless steel enclosure on rolling SS frame (trolley). Used in smoke studies of large clean rooms and for visual fog in stage acting.

about 15.5 cubic meters / minute

about 1520 ml liquid converted to fog each minute (fog density).
Adjustable fog volume and airflow velocity, optional wireless remote control.
2 internal water heaters and four 80mm fog outputs.
Includes LN2 FLOW CONTROL to prevent LN2 valve freezing.

Typical 90 minutes

Typical 30-40 feet visual fog airflow

LN2 + De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

AP100 ships in crate: 1.2 M x 1.2 M x 1.2M. Accessories are in separate rolling carry cases.

1) 80mm x 1.2 M Fog Wand
2) Wireless Remote Control
3) 5M x 80mm Fog Hose
4) Four 5M x 50mm Hose + 0.6M Fog Wands
5) Y Adaptor w/ Butterfly valves or plain Y Adaptor
6) 80mm T Adaptor
7) LED Fog Contrast Light
8) Accessory Rolling Carry Case w/ Foam Insert
9) 80mm x 2.4M Fog Wand for BSC, Isolator, cleanroom
10) 500mm Fog Nozzle
11) Drain & Dry Kit
12) Spare Dewar w/ SS valve control.

Integrated Power Supply & Power Cable, 115 VAC, 60 Hz; 100 VAC, 50 Hz; 220 VAC, 50 Hz.

Ultrapure LN2 Fogger from 2001 era

Medium fog volume.

about 1.5 cubic meters / ultrapure fog minute

about 250ml liquid converted to fog each minute (fog density).
Does not have LN2 Flow Control to prevent LN2 valve freezing.
Uses only 1 water heater and does not have Wireless Remote control.
1 internal water heater and 1 fog output.

Typical 40 minutes

Typical 10-15 feet visual fog airflow

LN2 + De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

Not Known.

80mm x 0.6M fog wand.

115 VAC, 60 Hz; 220 VAC, 50 Hz; 100VAC, 50 Hz.

CO2 Fogger

Low Cost fogger. For barrier isolators, bio-safety cabinets, fume hoods, glove boxes.

starts at about 0.30 cubic meters / minute, decreasing to 0 volume as CO2 evaporates over 8 minutes

starting at 20 ml / minute, and decreasing to 0 fog density as CO2 ice evaporates to zero.

Typical 8-10 minutes

Typical 4-6 feet visual fog airflow

CO2 ice + De-ionized Water, Sterile Water or WFI (Water for Injection) Water.

CO2 fogger ships in 22 x 22 x 18" Case.

Carry Case
Fog Wand
Ice Maker.

115 VAC, 60 Hz; 220 VAC, 50 Hz.

Low Cost, Hand Held, Glycol Fogger

Glycerin liquid and Water. Typically used in industrial and FDA applications. May leave a glycol film on surfaces, unless wiped clean.

about 0.30 cubic meters / minute

about 1.0 to 1.5 ml fog density / minute.

Typical 45 minutes

Typical 10-15 feet visual fog airflow

10% Glycerin liquid and 90% water, (Sterile, deionized or WFI).

Portable Fogger ships in box, 20 x 18 x 12 inches. All Accessories included in carry case.

Includes all accessories including:
Fog Wand
Carry Case
Power Charger
rechargeable Lithium ion battery
fog hose extension
bottle and filling tools.

Rechargeable Battery, 115V/220V Charging in 60 Minutes.

Feature / Fogger Comparison

Feature / Fogger

AP30 Ultrapure Fogger

AP50 Ultrapure High-Performance LN₂ Fogging for Airflow Visualization & Validation

AP200 Ultrapure - Maximum Fog Volume for Large-Scale Cleanroom Validation

Other LN₂ Foggers

Alternative Foggers

Fog Volume

4.3 m³/min

7.1 m³/min

28.6 m³/min

15-20 m³/min

3.5-10 m³/min

Fog Purity

100% Ultrapure LN₂ fog

100% Ultrapure LN₂ fog

100% Ultrapure LN₂ fog

Ultrapure LN₂ Fog

Chemical-Based Fog

Run Time

60 min

75 min

105 min

60-75 min

30-50 min

Residue-Free

Yes

Yes

Yes

Yes

No

Portable Design

Yes

Yes

Yes

Often Bulkier

Varies

Used in ISO 14644-3 / GMP smoke-study workflows

Yes

Yes

Yes

Yes

Some

Model Specifications

ModelTank/Water Size# PiezosOutput SizeFog Output Volume (m³/min)Water Consumption (ml/min)Output Distance (Est.)Notes
CRF2-H5–10 L9Single 60mm0.2648.1—
CRF2-J5–10 L12Single 80mm0.5664.1—
CRF420 L35Single 80mm1.25187—
Old CRF39–11 L25Single 80mm0.9133.5—
New CRF39–11 L24Dual 80mm1.2

Cleanroom Foggers Fog Comparison

Model

Design / Enclosure

Fog Application

Fog Volume (m3/min)

Duration (min)

Duration Display

Fog View Distance

Fog Outlets

Status

Notes

Accessories

Power / Notes

CRF2-H

Polyethylene enclosure, 9 ultrasonic piezos, single 60mm outlet

Fume hoods, small glove boxes, small airflow hoods

0.28

45

45

6-7 feet

One 60mm fog outlet

Current

22" fog curtain wand; 10 ft remote cable; rolling carry case; drain & dry kit

DI / Sterile / WFI water; separate power supply; 115/220 VAC

CRF2-J

Polyethylene enclosure, 12 ultrasonic piezos, single 80mm outlet

Medium glove boxes, RABs, small BSCs, small airflow hoods

0.43

35

35

8-10 feet

One 80mm fog outlet

Current

0.6M 80mm wand; wireless remote; 2M x 80mm hose; Y/T adaptors; LED light

DI / Sterile / WFI water; integrated power; 115/100/220 VAC

2022 CRF3 (Discontinued)

316L electro-polished stainless enclosure, 25 ultrasonic piezos, single 80mm outlet

Small BSCs, barrier isolators, RABs, medium glove boxes

0.89

70

70

about 10 feet

One 80mm fog outlet

Discontinued

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light

DI / Sterile / WFI water; integrated power; 115/100/220 VAC

2025 CRF3 (Current)

316L electro-polished stainless enclosure, 24 ultrasonic piezos, dual 80mm outlets

Small / medium BSCs, barrier isolators, RABs, medium glove boxes

1

62

62

10-12 feet

Two 80mm fog outlets

Current

Runtime estimated from 2022 CRF3 using inverse fog-volume scaling.

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light

DI / Sterile / WFI water; integrated power; 115/100/220 VAC

Legacy CRF4

316L electro-polished stainless enclosure, 35 ultrasonic piezos, single 80mm outlet

Medium BSCs, barrier isolators, RABs, medium cleanroom smoke studies

1.4

45

45

12-15 feet

One 80mm fog outlet

Discontinued

Runtime estimated from 2022 CRF3 using inverse fog-volume scaling.

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

2022 CRF6 (Discontinued)

316L electro-polished stainless enclosure, 40 ultrasonic piezos, dual 80mm outlets

Medium BSCs, RABs, barrier isolators, small cleanrooms, sterile smoke studies

2

35

35

12-15 feet

Two 80mm fog outlets

Discontinued

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

2025 CRF6 (Current)

316L electro-polished stainless enclosure, 48 ultrasonic piezos, dual 80mm outlets

Medium / large BSCs, RABs, barrier isolators, small cleanrooms, sterile smoke studies

2.4

26

26

14-17 feet

Two 80mm fog outlets

Current

Runtime estimated from 2022 CRF3 using inverse fog-volume scaling.

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP35

316L electro-polished stainless trolley unit, passive/dewar 35L tank, dual heaters, dual 80mm outlets

Small ISO suites, medium barrier isolators, glove boxes

8.5

70

70

15-20 feet

Two 80mm fog outlets

Current

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP30

316L electro-polished stainless trolley unit, self-pressurized 30L tank, dual heaters, dual 80mm outlets

Small ISO suites, medium barrier isolators, glove boxes

7.4

60

60

15-20 feet

Two 80mm fog outlets

Current

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP50

316L electro-polished stainless trolley unit, self-pressurized 50L tank, dual heaters, dual 80mm outlets

Small / medium ISO suites, medium barrier isolators, glove boxes

12.2

75

75

18-22 feet

Two 80mm fog outlets

Current

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP95

316L electro-polished stainless trolley unit, passive 95L tank platform, dual heaters, dual 80mm outlets

Medium / large ISO suites, barrier isolators, large glove boxes, cleanroom airflow validation

15.2

89

89

18-21 feet

Two 80mm fog outlets

Current

Passive 95L estimate aligned to corrected AP-family baseline logic.

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP100

316L electro-polished stainless trolley unit, self-pressurized 100L tank, dual heaters, dual 80mm outlets

Medium / large ISO suites, barrier isolators, large glove boxes and BSCs

20.5

90

90

22-26 feet

Two 80mm fog outlets

Current

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP175

316L electro-polished stainless trolley unit, passive 175L tank platform, dual heaters, dual 80mm outlets

Large ISO suites, large cleanrooms, large barrier isolators, large-scale airflow validation

28

101

101

24-27 feet

Two 80mm fog outlets

Current

Passive 175L extrapolated from corrected AP-family baseline logic.

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

AP200

316L electro-polished stainless trolley unit, self-pressurized 200L tank, dual heaters, dual 80mm outlets

Large ISO suites, large cleanrooms, large barrier isolators, large-scale airflow validation

49

105

105

33-37 feet

Two 80mm fog outlets

Current

Distance shown marketing-forward from corrected 200L projection.

80mm wand; wireless remote; 5M x 80mm hose; dual 50mm hose set; Y/T adaptors; LED light; drain & dry kit

LN2 + DI / Sterile / WFI water; integrated power; 115/100/220 VAC

Current Applied Physics Fogger Family

CRF ultrasonic or AP Series LN₂?

Use this matrix as a starting point. Product selection should follow the current quoted configuration and the actual study geometry; restrictive delivery paths should never be sized from a room-volume or free-air figure alone.

ModelTechnologyBest starting pointSelection status / fact
CRF2UltrasonicLocalized studies, hoods, small enclosuresCompact current CRF platform; confirm the quoted product sheet.
CRF3UltrasonicMid-range cleanroom / enclosure studiesMid-range current CRF platform; confirm the quoted product sheet.
CRF6UltrasonicHigher-output portable ultrasonic studies48 piezos · dual 80 mm outlets · ≈2.4 m³/min · 7-inch HD display.
AP35LN₂ · passive/dewar35 L passive/dewar AP Series optionCurrent passive/dewar architecture.
AP30LN₂ · self-pressurizedCompact self-pressurized AP Series optionCurrent self-pressurized architecture; not a replacement for AP35.
AP50LN₂ · self-pressurizedIntermediate self-pressurized AP Series optionCurrent self-pressurized platform; confirm quoted performance.
AP95LN₂ · passive/dewarHigher-capacity passive/dewar AP optionCurrent passive/dewar platform; confirm quoted performance.
AP175LN₂ · passive/dewarLargest passive/dewar AP Series optionCurrent passive/dewar platform; confirm quoted performance.
AP100LN₂ · self-pressurizedHigher-capacity self-pressurized AP optionCurrent self-pressurized platform.
AP200LN₂ · self-pressurizedLargest self-pressurized AP Series optionCurrent self-pressurized platform for larger-scale planning.

AP Series architecture note:

AP Series LN₂ foggers are offered in two current architecture families. Self-pressurized models include AP30, AP50, AP100 and AP200. Passive/dewar-style models include AP35, AP95 and AP175. Choose the architecture from the application, handling preference, study duration and fog-delivery path rather than treating one architecture as the successor to the other.

Delivered fog matters more than free-air output.

Hose length, diameter, bends, Y/T adapters, a restrictive injection port and enclosure pressure can all reduce or redistribute the fog that actually reaches the test area. For isolators and RABS, evaluate the intended delivery path under representative pressure conditions.

The quote should identify the actual application, enclosure/room dimensions, pressure relationship, hose/port geometry and study objective so Applied Physics can recommend the appropriate configuration.

Technology Selection

Use CRF for ultrasonic portability; use AP Series when LN₂-based fog is the requirement

CRF Series · Ultrasonic

CRF2, CRF3 and CRF6 generate visible fog ultrasonically from the appropriate water supply. The family spans compact localized studies through the confirmed high-output CRF6.

AP Series · LN₂

The current AP Series is organized by architecture: self-pressurized AP30, AP50, AP100 and AP200, and passive/dewar AP35, AP95 and AP175. Select between architectures based on the actual study and handling requirement.

Delivered fog matters more than free-air output.

Hose length, diameter, bends, Y/T adapters, a restrictive injection port and enclosure pressure can all reduce or redistribute the fog that actually reaches the test area. For isolators and RABS, evaluate the intended delivery path under representative pressure conditions.

Fogger Sizing · Application First

Do not size a cleanroom fogger from room volume alone

Room or enclosure volume is useful context, but it does not describe the resistance between the fogger and the point where the tracer must be visible. The sizing decision should capture the complete delivery path and the evidence the study needs to produce.

1 · Geometry

2 · Restriction

3 · Study objective

Delivered fog matters more than free-air output.

Hose length, diameter, bends, Y/T adapters, a restrictive injection port and enclosure pressure can all reduce or redistribute the fog that actually reaches the test area. For isolators and RABS, evaluate the intended delivery path under representative pressure conditions.

Two outlets into one hose?

Combining two fogger outlets through a reverse Y into a single downstream hose can add restriction and backpressure. Where practical, preserve separate delivery paths or use a manifold/downstream line sized for the combined flow. If a combined line is required, validate that exact hose and enclosure configuration before the formal study.

Fog Delivery Accessories

Treat hoses, wands and adapters as part of the airflow-visualization system

The same fogger can behave very differently depending on how the fog is delivered. The accessory plan should support visibility without creating a tracer jet that overpowers the airflow being observed.

Hoses

Use the shortest practical route and avoid unnecessary reductions. Long flexible runs and small downstream diameters increase resistance.

Wands / nozzles

Use a wand, curtain or diffuser when the study needs fog distributed across a wider region or introduced at lower local momentum.

Y / T adapters

Use splitters to serve multiple injection points only after considering the resulting balance and restriction. Valved branches can help tune the distribution.

For isolators and RABS

For video quality

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