CRF5 Cleanroom Fogger – Available in December 2023

Cleanroom Fogger Performance Comparisons

CRF4 Cleanroom Fogger VIDEO

CRF2 Cleanroom Fogger VIDEO

AP35 Ultrapure Fogger VIDEO


CRF5 Cleanroom Fogger with 24 Piezos, 1.0 Cubic Meters fog per minute with Dual 80mm fog outlets; Stainless Steel design & enclosure, Touch Screen Control


The CRF5 Cleanroom Fogger is an advanced ultrasonic, water based, fogger using 24 high performance, piezos to produce 1.0 cubic meters per minute (39 cubic feet per minute) of pure fog with a fog density of 117 ml fog density per minute for a typical 40 minute operation. This provides about 10-15 feet of visual fog using TOUCH SCREEN control of airflow velocity and fog volume through one or two 80mm fog outlets for smoke studies and air flow characterization in small areas such as fume hoods, airflow hoods, glove boxes and small bio-safety cabinets. 12 accessories are available to adapt the fog outlet to nearly any smoke study requirement. The CRF5 is compatible with USP 797 Pharmaceutical In-situ Airflow Analysis; USP 800 Compound Pharmacy airflow tests; Airflow Recovery Tests in ISO 14644-3 Annex B12; Airflow Visualization Tests for ISO 14644-3 Annex B7; NSF 49 for Bio-Safety Cabinets; and Semi-Standards Clean Room Guidelines, Federal Standard 209E.



Title Range Discount
Quanitity Discount 3 + 10%
Discounts are available for purchases of quantity 5 or more.

CRF5 Cleanroom Fogger produces ≈ 1.0 cubic meters of fog / min. through two 80mm fog outlets with ≈ 171 ml fog density / min., ≈ 40 minutes operation for ≈ 10-15 feet visual fog distance. Touch screen control of fog velocity, diagnostics and fog volume

The CRF5 stainless steel fogger provides touch screen, adjustable control of fog volume, fog velocity and provides a diagnostic screen with temperature, water level transducer curent, etc. Fog output is through two 80mm fog outlets which can be connected to a broad variety of accessories to support almost any smoke study needed.  Typical 40 minute operation at max parameters of 100% airflow and ≈ 171 ml fog density per minute with both transducers turned on. You may only need 50% velocity and 1 transducer with one output. No problem. Use deionized, sterilized or WFI water. The CRF5 controls the water height above the 24 ultrasonic piezos for maximum fog produced at any moment. Use the CRF5 in smoke studies of a clean room, ISO suite, sterile room, RAB, BSC, barrier isolator or glove box. The fog evaporates back to air we breathe with no contamination or clean room wipe down necessary.

The CRF5 Cleanroom Fogger is typically used in Bio Safety Cabinets, Barrier Isolators, Glove Boxes, small clean rooms, fume hoods and airflow hoods to visualize airflow patterns, turbulence and balance. The CRF5 produces 1.0 cubic meters pure fog per minute in smoke tests of ISO suites and pharmaceutical and semiconductor clean rooms. Pharmaceutical Metrology Managers are guided by USP 797 In-situ Airflow Analysis and ISO 14644-3, B7 guidelines for smoke studies. Airflow Recovery tests using PSL spheres in the CRF5 Cleanroom Fogger are guided by ISO 14644-3, B-12. The CRF5 is an advanced capability fogger by controlling the water level over the transducers, thus producing a constant fog at a maximum efficiency. It provides touch screen control, 0-100% of Airflow velocity, select 0, 1 or 2 fog transducers for fog volume; and uses a secondary water chamber to extend the life of fog production, as well as controlling the water height in the primary water chamber. It also provides a diagnostic screen of the internal operating parameters.

Cleanroom Fogger, CRF5 Features -

  • 3x5 inch, Touch Screen control of airflow velocity, fog volume, Diagnostics; with real time clock on the display
  • 12 piezos per transducer with 2 transducers in the CRF5 converting DI Water, Sterile or WFI water directly to pure fog for up to 40 minutes
  • Quick refill of Di Water, Sterile or WFI water using a dedicated water input for continuous fog use
  • Easy to Fill total of 11.34 liters of pure water
  • Primary water chamber of 6 liters to start the fog using one or two fog outlets
  • Secondary Reserve water chamber of 5.3 liters to extend fog life and control water level above the two transducers
  • Electronic Water Level Indicator and water temperature provided
  • Two 80mm fog outlets for single or dual fog output using 80mm fog hoses or 50mm fog hose
  • Fogger Handles for easy transport of fogger from point to point
  • Stainless Steel enclosure is durable and can be used in any clean room
  • Optional Fog Wands, fog hoses, fog nozzles, fog lighting system: 12 different accessories are available
  • 80mm fog hose diameter is standard and provides a 5M length, which can be cut to your exact needs
  • Built in power supply and touch screen fogger controls to provide higher fog volume in a smaller fogger footprint
  • 110VAC, 100VAC or 220VAC compatible
  • Easy to use, quick operation set up, instant On/Off fogging operation
  • Rolling Carry Case, optional, for carry and storage of Cleanroom Fogger
  • Instructions and applications on the back side of the CRF5, no paper manual needed in the clean room

In 2001 cleanroom foggers were developed, and since then, Applied Physics has supported smoke studies and smoke tests using a variety of cleanroom foggers. You can review cleanroom fogger performance for your smoke study. Our CRF5 portable fogger uses 24 ultrasonic piezo devices to produce a pure fog, based on the quality of water used. It is an advanced design fogger in that it controls the water height above the piezo devices in order to produce a maximum amount of fog, whether you have 1 or 2 transducers turned on. Each transducer has 12 ultrasonic piezos, and you can instantly select the number of transducers needed for fog volume at any time. Using the TouchScreen Control, you can simply touch the velocity control for up to 100% fog velocity to tune the fog output to your smoke study requirements. The two 80mm fog outlets allows for single fog hose operation or dual fog hose operation. The CRF5 is very flexible with 12 different accessories, quick fill capabilities, easy fog control, high fog output, and quick drain capabilities.  The CRF5 fogger fills with 11.4 liters and uses to two high output transducers with 20 piezo devices total to produce fog through two 80mm fog outlets. Fog density is 171 ml per minute, which creates about 1.0 cubic meters pure fog per minute during a typical 40 minutes of operation. You can use Deionized water, commonly called DI Water, Sterile water or Water for Injection, known as WFI water to produce a pure fog to visually observe airflow patterns, velocity, turbulence and balance in semiconductor clean rooms, pharmaceutical ISO suites, bio-safety cabinets, barrier isolators, BSC, compound pharmacies and medical rooms. The CRF5 is also used in ISO 3, ISO 5, ISO 7 and ISO 9 suites. The CRF5 provides instant on fog with adjustable fog volume control, and adjustable fog velocity control using two 80mm fog outlets and an array of accessories to match almost any smoke study requirement.

Cleanroom Fogger, ISO Suites, Sterile Rooms

  • Supports airflow visualization tests supporting ISO 14644-3, B7
  • Supports airflow visualization analysis, USP 797 Guidelines
  • Supports 100:1 Airflow Recovery Test, as defined in ISO 14644-3, B12
  • Supports airflow tests, NSF 49 National Safety Foundation
  • Supports airflow visualization, USP 800 Hazardous Drug Compounding
  • Supports Semiconductor Semi-Standards Guidelines
  • Air flow and pressure balance between two clean areas
  • Leak detection of exhaust ducts
  • Barrier Isolator and laminar flow tests
  • Wet bench exhaust tests
  • Personal safety exhaust tests
  • Stainless Steel design to support any smoke study including chemical process equipment, exhaust ventilation tests

Compare Cleanroom Fogger

Product Model CRF5 Portable Cleanroom Fogger CRF2 Cleanroom Fogger Small LN2 Foggers
FOG Minutes ~ 40 minutes ~ 50 minutes ~ 20-40 minutes
FOG Volume Meters/Min. ~ 1.0 cubic meters / minute ~ 0.26 cubic meters / minute ~ 0.8 to 1.5 cubic meters / minute
Total FOG Volume ~ 43 cubic meters ~ 13 cubic meters ~ 16 to 60 cubic meters
Fog Density (ml/minute) ~ 171 mL / minute ~ 57 mL / minute ~ 150ml to 260 mL / minute
Visual Fog Distance ~ 10 to 15 feet using Dual Fog Hose output ~ 6 feet ~ 10 feet
Adjustable Fog Volume Yes, thru TouchScreen Cotrol No fog volume control No fog volume control
Adjustable Airflow Velocity Yes, thru TouchScreen Cotrol No airflow control No airflow control
Fogger Technology Ultrasonic with water level control Ultrasonic Ultrapure
Liquids Used DI Water, WFI or Sterile water DI Water, WFI or Sterile water LN2 + DI Water
Typical Use
BSC, Barrier Isolator, Cleanroom Clean room, sterile room ISO suite Clean room, sterile room ISO suite
Fog Outlets Two 80mm fog outlets One 60mm fog outlet One 60mm fog outlet
Compatible Guidelines USP 797 & ISO 14644-3, Annex B7 USP 797 & ISO 14644-3, Annex B7 USP 797 & ISO 14644-3, Annex B7
Compatible Guidelines Federal Standards 209E Federal Standards 209E Federal Standards 209E
Compatible Guidelines ISO Standard 14644-1, 14644-2 ISO Standard 14644-1, 14644-2 ISO Standard 14644-1, 14644-2
DI / WFI Water Volume 11.34 liters 3.75 liters 2 liters
LN2 Volume No LN2 used No LN2 used 9 liters
Operator Control TouchScreen Cotrol
Power Switch, no fog controls Power Switch, no fog controls
Remote Control Optional No No Wireless Remote Control of fog
Handling Carry Handles, Side
Carry Handle (top) Carry Handles (top)
Enclosure Stainless Steel Polyethylene Stainless Steel
Power VAC 120, 220, 100 VAC 120, 220, 100 VAC 120, 220, 100 VAC
Full Weight with Water
~ 55 lbs ~ 20 lbs ~ 50-75 lbs
Accessories 12 Accessories 8 Accessories
Several Accessories


The CRF5 smoke machine is used in smoke studies as a smoke generator. It is a low cost device providing excellent volumes of fog in support of smoke studies. It is designed with stainless steel for operation in nearly any smoke study. Operation instructions are located on the rear panel, so there is no paper manuals needed in the pharmaceutical ISO suite, sterile room, laboratory or clean room.

Theory of Operation: Ultrasonic cavitation using DI water, Sterile water or Pharmaceutical WFI Water. Use of any other liquid or chemical voids the warranty.

Transducers include a low water interlock and a high temperature interlock during operation. There is also a mechanical water level level sensor that will interrupt the input voltage to the transducer module, should the water level drop to low for operation.

  1. The fog generated by this device contains microscopic droplets of Deionized, Sterile or WFI (water for Injection) water. AVOID USING IN IMMEDIATE VICINITY OF ELECTRICAL APPLIANCES, WATER SENSITIVE PRODUCTS AND EQUIPMENT.
  2. Use the optional Drain and Dry kit is available to drain water and dry the two water cavities prior to CRF5 fogger storage.
  3. The CRF5 is intended to be used on a flat surface. Tipping the fogger with water in the reservoir may damage the fogger electronics. DO NOT OVERFILL OR TIP THE FOGGER DURING OPERATION OR DURING DRAIN CYCLE.

Which Cleanroom Fogger or Smoke Generator Is Best For Smoke Studies?

AP35 Ultrapure Fogger, 5 Cubic Meters per minute for 70 minutes with 20-30 feet visible distance.
  • When ultrapure fog purity with high volume of fog and long visible airflow is needed
  • To visualizing airflow in large clean rooms, ceiling to floor
  • To fog exit velocity must not create turbulence
  • To needing to do 3D airflow modeling of airflow
  • When needing to do visualize airflow in larger clean rooms
  • When 70 minutes of high purity fog duration is needed
  • When fog visibility of 20-30 feet distance is required
  • To fog Class 1 to Class 10,000 semiconductor, medical, pharmaceutical cleanrooms
AP100 LN2 UltraPure Fogger, 15.5 Cubic Meters fog per minute for 70 minutes with 30-40 feet visible distance.
  • When ultrapure fog is needed to support large cleanrooms
  • Four Fog hoses and two water heaters are provided to disperse 15.5 cubic meters fog per minute
  • High levels of fog density to visualize airflow for 30-40 feet
  • For 3D airflow modeling of ISO suites, sterile rooms, cleanrooms
  • 9 Accessories available to configure the AP100 to your clean rooms
  • Fog large hallways and large clean areas
  • Fog for longer distances of 30-40 feet
  • Supports ISO 14644-3 and USP 797 airflow guidelines for your smoke study

* Use Hand Gloves and Face Shield when filling LN2
Use 16 Megohm DI water or WFI Pharmaceutical Water

CRF2 Cleanroom Fogger, 9cfm, 50 minutes Operation
  • When budget is lower, basic Fogger OK, minimal output turbulence
  • When 50 minutes of fog duration is useful with quick turnaround
  • When fog visibility for 6-7 feet distance is acceptable
  • When fogging gray areas behind the clean room
  • When fogging ≥ Class 10 or above in semiconductor or pharmaceutical clean rooms
CO2 Fogger, Vapor DiH2O Fogger, average 4cfm over 10 minutes
  • When Fogging Hazardous areas, No Electrical Outlet Available
  • When fog visibility for 5-6 feet distance is acceptable
  • When 10 minutes of fog duration is useful
  • When fogging small areas
  • Class 10 or above in semiconductor or pharmaceutical clean rooms
  • When fogging work benches

16 Meg ohm De-Ionized water, WFI water or Sterile water
Do not permit DI Water to go stagnant in the water chamber
** Use gloves when handling CO2 ice

Fogger Technology

The two types of foggers manufactured for use in cleanrooms, ISO suites and sterile rooms are described below.

Ultrapure LN2 Fogger: LN2 foggers use liquid nitrogen and DI Water or WFI water, providing the highest fog volume, highest fog density and best level of fog purity fog. Fog purity is allowing the LN2 to boil, while heating the water. nitrogen and water molecules form and combine at high rates to create a fog vapor. This process removes any bacterial agents and residual particulate matter from the water vapor. The volume of fog produced depends on the version of LN2 fogger purchased. The AP35 Ultrapure Fogger converts 571 ml of water per minute, a high fog density, which generates 5 cubic meters of fog for about 70 minutes to visualize airflow for 20-30 feet. The AP100 LN2 Fogger converts 1520 ml of water per minute, a very high fog density, to produce 15.5 cubic meters of ultrapure fog for about 70 minutes visualizing air flow for about 30-40 feet using 4 fog outputs. The fog is ultrapure leaving minimal, if any, trace particles behind. It evaporates to its gaseous hydrogen, oxygen and nitrogen components, which are natural to the cleanroom environment. LN2 foggers are used in a Class 1 - 10,000 cleanrooms.

DI Water Fogger: This type of fogger has less fog density (less capability to visualize airflow) than the LN2 ultrapure foggers described above. The DI water fog is generated by cavitation in water, producing a water vapor of 8-10 microns in diameter. If the facility manager operates a class 10 to Class 10000 Clean room, the use of a DI Water Fogger poses no problem. However, Cleanroom Metrology Managers in fabs or labs operating at Class 1 to Class 10 performance may desire to use an ultrapure fogger. Although some DI Water foggers are described as ultrapure, unless the DI water is heated or boiled to remove possibility of bacterial agents, the fog is pure based on the quality of water used.

CRF5 Cleanroom Fogger From Applied Physics Inc.CRF2 Cleanroom Fogger From Applied Physics Inc.

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